Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs
By A. Jabłońska-Trypuć, M. Matejczyk, S. Rosochacki. Journal of Enzyme Inhibition and Medicinal Chemistry, 2016
941 citations recorded by the source corpus.
Subfields: Cultural Studies, Literature and Literary Theory
View Paper: https://www.semanticscholar.org/paper/563d7ad46fb5151bba18ccea0c61e52ea37ba4f4
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Citations in the corpus
- Role of Matrix Metalloproteinases in Angiogenesis and Cancer (2019, methodology): “All MMPs are produced as proenzymes and require a proteolytic cleavage under physiological conditions to promote the release of the propeptide domain (zymogen activation) and generate mature MMPs (22).”
- Tumor microenvironment complexity and therapeutic implications at a glance (2020, background): “ECM may act as a barrier for drug delivery through increased tissue stiffness and desmoplasia or a gate for breaching the basement membrane to promote metastasis [2, 122] .”
- The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases (2020, background): “MT-MMPs have collagenolytic activity and may activate some proteases and components of the cell surface (Table 1) [1,3].”
- Role of Extracellular Matrix in Development and Cancer Progression (2018, background): “As a highly dynamic structure, the ECM is constantly undergoing a remodelling process, by which components are degraded and modified, facilitated primarily by ECM proteinases [5,6].”
- Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity (2021, background): “It is well established that canonical cancer cell migration including EMT-mediated mesenchymal pattern or collective pattern required the proteolysis-dependent ECM degradation to leave paths for cell invasion.(265,266,269) During this process, the cellular actin dynamics, integrin-based ECM adhesion”
- Silver nanoparticles: Synthesis, medical applications and biosafety (2020, background): “MMPs play a dominant role in tumor progressions, such as tumor cell proliferation, invasiveness and distant metastasis, evasion of immune surveillance, and angiogenesis [267, 268].”