Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.
By C. Fryer, J. White, K. Jones. Molecules and Cells, 2004
678 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/5637d256b9b4e30750b4bb6925288b5e4e76a4e9
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In Genetics
In Molecular Biology
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- Richard A. Young
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- Rickard Sandberg
- Raphael Kopan
- U. Lendahl
Citations in the corpus
- CDK8/9 drive Smad transcriptional action, turnover and YAP interactions in BMP and TGFβ pathways (2009, positive): “In mammalian cells, CDK8 phosphorylates the ICD signal transduction component of Notch, targeting it to the Fbw7/Sel10 ubiquitin ligase (Fryer et al., 2004).”
- Hypoxia requires notch signaling to maintain the undifferentiated cell state. (2005, result): “These results are in agreement with ecently published observations regarding the Hes-1 romoter (Fryer et al., 2004).”
- The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism (2009, background): “One such regulation point occurs during the transcriptional activation process, wherein NICD is phosphorylated within the PEST domain by the CDK8 kinase and targeted for proteasomal degradation by E3 ubiquitin ligases that include Sel10/Fbw7 (Fryer et al., 2004; O’Neil et al., 2007; Thompson et al.,”
- Notch signaling: the core pathway and its posttranslational regulation. (2009, background): “…resulting signal attenuation is mediated by ubiquitination and proteosomal degradation of NICD by the E3 ubiquitin ligase Fbw7 (mammals)/ SEL-10 (C. elegans), involving phosphorylation of NICD on its Cterminal PEST domain by cyclin-dependent kinase 8 (Fryer et al., 2004; Tsunematsu et al., 2004).”
- Control of Embryonic Stem Cell State (2011, background): “The CDK8 kinase subunit of the mediator complex can influence the activity of signaling transcription factors (Alarcon et al., 2009; Fryer et al., 2004; Gao et al., 2009; Taatjes, 2010).”
- Notch signaling: simplicity in design, versatility in function (2011, methodology): “Fbxw7/Cdc4 F-box/WD repeat protein 7 Ubiquitylates Notch ICD, leading to its degradation (Fryer et al., 2004; Gupta-Rossi et al., 2001; Oberg et al., 2001; Wu et al., 2001; Tsunematsu et al., 2004)”