The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria.

By P. Nordmann, G. Cuzon, T. Naas. Lancet. Infectious Diseases (Print), 2009

1,614 citations recorded by the source corpus.

Subfields: Endocrinology, Molecular Biology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/562f6330da8fc3b74eb0c40b19ac4d6d95a06ae0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

1. P. Nordmann
2. L. Poirel
3. J. Pitout
4. F. Codjoe
5. E. Donkor
6. G. Meletis
7. T. Naas
8. Robert A. Bonomo

In Molecular Biology

1. L. Poirel
2. P. Nordmann
3. G. Meletis
4. T. Naas
5. Robert A. Bonomo
6. L. Logan
7. Robert A. Weinstein
8. F. Codjoe

In Molecular Medicine

1. P. Nordmann
2. L. Poirel
3. G. Meletis
4. J. Pitout
5. F. Codjoe
6. E. Donkor
7. T. Naas
8. Robert A. Weinstein

Citations in the corpus

• Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. (2012, neutral): “coli and other enterobacterial species [135,138].”
• Carbapenem Resistance: A Review (2017, background): “KPC producers have evolved to be multidrug resistant to β-lactams thereby limiting therapeutic options for treating KPC-related infections in patients [67].”
• Emerging broad-spectrum resistance in Pseudomonas aeruginosa and Acinetobacter baumannii: Mechanisms and epidemiology. (2015, background): “Another class A carbapenemase that is commonly identified among Enterobacteriaceae is KPC, with KPC-type enzymes possessing intrinsic high carbapenemase and ESBL activity [86].”
• Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry: a Fundamental Shift in the Routine Practice of Clinical Microbiology (2013, background): “pneumoniae is known to be a significant cause of nosocomial infections and a reservoir for the accumulation and dissemination of antibiotic resistance determinants among endogenous bacteria (334).”
• Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy. (2012, background): “Effective treatment of infections caused by these pathogens is thus a considerable challenge for clinicians [1–3].”
• Characterization of a New Metallo-β-Lactamase Gene, blaNDM-1, and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India (2009, background): “However, carbapenemases are increasingly being reported; and the most prevalent of these would appear to be KPC, which has recently been characterized in the United States, Israel, Turkey, China, India, the United Kingdom, and Nordic countries (20, 24, 26).”
• Global Dissemination of Carbapenemase-Producing Klebsiella pneumoniae: Epidemiology, Genetic Context, Treatment Options, and Detection Methods (2016, background): “Carbapenems (imipenem, meropenem, biapenem, ertapenem, and doripenem) are antibiotics used for the treatment of severe infections caused by multi-resistant Enterobacteriaceae, such as Klebsiella pneumoniae and Escherichia coli (Nordmann et al., 2009).”
• Antimicrobial Resistance in ESKAPE Pathogens (2020, background): “pneumoniae ST258) and hydrolyze virtually all -lactams, including carbapenems (148).”
• Mechanisms of Antibiotic Resistance (2016, background): “A total of 22 variants of the bla KPC gene have been described to date, most of them located in plasmids harboring trans-posable elements (e.g., Tn 4401 ) or in association with insertion sequences such as ISKpn6 and ISKpn7 (26).”
• Carbapenem resistance: overview of the problem and future perspectives (2016, background): “Among the class A carbapenem-hydrolyzing enzymes, KPCs presented the most rapid and geographically extended dissemination [Nordmann et al. 2009].”
• The Role of Epidemic Resistance Plasmids and International High-Risk Clones in the Spread of Multidrug-Resistant Enterobacteriaceae (2015, background): “bacteria are endemic are shown in Table 1 (28).”
• The difficult-to-control spread of carbapenemase producers among Enterobacteriaceae worldwide. (2014, background): “In Israel the endemicity of KPC producers has been demonstrated through many studies, with lots of nosocomial reports but also, noticeably, with some community-occurring cases [29,33].”