Domoic acid binds iron and copper: a possible role for the toxin produced by the marine diatom Pseudo-nitzschia

By Eden L. Rue, K. Bruland. 2001

205 citations recorded by the source corpus.

Subfields: Analytical Chemistry, Environmental Chemistry, Health, Toxicology and Mutagenesis

View Paper: https://www.semanticscholar.org/paper/5616eec265715c9ac832799c0523d40fc45e5eff

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Analytical Chemistry

1. Stephen Bates
2. V. Trainer
3. Nina Lundholm
4. Raphael M. Kudela
5. W. Cochlan

In Environmental Chemistry

1. P. Glibert
2. Raphael M. Kudela
3. W. Cochlan
4. C. Gobler
5. V. Trainer
6. J. Burkholder
7. Stephen Bates
8. D. Anderson

In Health, Toxicology and Mutagenesis

1. W. Cochlan
2. Raphael M. Kudela
3. V. Trainer
4. Stephen Bates
5. E. Virginia Armbrust
6. P. Soudant
7. C. Gobler

Citations in the corpus

• The distribution and impacts of harmful algal bloom species in eastern boundary upwelling systems (2010, background): “, 1991); and the effects of micronutrient (Fe, Cu) conditions (Maldonado et al., 2002; Rue and Bruland, 2001).”
• The role of nutrients in regulation and promotion of harmful algal blooms in upwelling systems (2010, background): “…triggers for increased domoic acid production in culture studies (Bates, 1988; Pan et al., 1996a,b), although Fe and Cu stress have also been implicated in both the laboratory and field (Rue and Bruland, 2001; Maldonado et al., 2002; Ladizinsky, 2003; Wells et al., 2005; Trick et al., 2010).”
• Pseudo-nitzschia physiological ecology, phylogeny, toxicity, monitoring and impacts on ecosystem health (2012, background): “Significant findings by Rue and Bruland (2001) documented that the high stability constants of copper and iron to DA may provide an important ecological role as an iron-siderophore, keeping iron soluble and bioavailable in the environment for retrieval by Pseudo-nitzschia , or as a means of copper…”
• Interactions between Diatoms and Bacteria (2012, background): “DA has been hypothesized to play a role in acquisition of both metals (150), and production of DA appears to increase when Pseudo-nitzschia cells are Fe limited or Cu stressed (with a low or high copper concentration) (114, 184).”
• Nitrogenous preference of toxigenic Pseudo-nitzschia australis (Bacillariophyceae) from field and laboratory experiments (2007, background): “Previous authors have suggested a number of potential environmental factors such as coastal runoff (Scholin et al., 2000), metal stress ( Rue and Bruland, 2001; Maldonado et al., 2002; Ladizinsky and Smith, 2003; Wells et al., 2005) or macronutrient limitation (Pan et al., 1996a,b,c) that may trigg”
• Eutrophication and Harmful Algal Blooms: A Scientific Consensus (2008, background): “For example, laboratory studies have shown that the toxigenic diatoms Pseudo-nitszchia multiseries and P. australis produce increasing amounts of DA as a function of iron or copper limitation (Rue and Bruland, 2001; Maldonado et al., 2002; Wells et al., 2005).”
• Production and Toxicity of the Marine Biotoxin Domoic Acid and Its Effects on Wildlife: A Review (2008, background): “In the Monterey Bay area, where Pseudo-nitzschia blooms have occurred frequently (see below), large-scale features including floor topography, water circulation, and proximity to a major coastal upwelling may be favorable to the development and maintenance of algal blooms, as they influence the spat”
• Pseudo-nitzschia (Bacillariophyceae) species, domoic acid and amnesic shellfish poisoning: revisiting previous paradigms (2012, background): “Values for the conditional stability constant of DA binding to iron and copper indicate that environmental concentrations of DA can compete for these trace metals with natural ligands in the seawater (Rue & Bruland 2001).”
• Predicting potentially toxigenic Pseudo-nitzschia blooms in the Chesapeake Bay (2010, background): “Lastly, future efforts to model HABsmust look closely at the combined effects of inorganic and organic nutrient uptake, trace metal utilization (e.g. Rue and Bruland, 2001; Maldonado et al., 2002; Wells et al., 2005), allelopathic competition (e.g. Adolf et al., 2008), and grazing (e.g. Bargu et…”
• Harmful algal blooms along the North American west coast region: History, trends, causes, and impacts (2012, background): “related to DA production in laboratory and field studies (Rue and Bruland, 2001; Trainer et al., 2009b).”
• Empirical models of toxigenic Pseudo-nitzschia blooms: Potential use as a remote detection tool in the Santa Barbara Channel (2009, background): “DA synthesis has been linked to physiological stress in the form of silicon-, phosphate-, iron-, or copper-limitation (Pan et al., 1998; Rue and Bruland, 2001; Maldonado et al., 2002; Bates et al., 1998; Wells et al., 2005), and toxicity is not always correlated to the abundance of Pseudo-nitzschia…”
• Harmful algal blooms and eutrophication: Examining linkages from selected coastal regions of the United States (2008, background): “Limitation by Fe directly modulates Si:N ratios in diatoms, as DA may serve as an Fe-acquisition mechanism (Rue and Bruland, 2001; Wells et al., 2005).”
• The Ecology of Harmful Diatoms (2006, background): “Fe- and Cu-stressed P. multiseries and P. australis cells produce increasing amounts of dissolved and particulate DA during the exponential phase ( Rue and Bruland 2001; Maldonado et al. 2002; Wells et al. 2005).”