The classical complement cascade mediates CNS synapse elimination.

By Beth Stevens, N. J. Allen, L. E. Vazquez, G. Howell, K. S. Christopherson, Navid Nouri, Kristina D. Micheva, A. Mehalow, A. Huberman, Benjamin K. Stafford and 6 more. Cell, 2007

3,118 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/5606541fe216bbd09fcc5612e610589b1683ee99

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. M. Sofroniew
2. M. Pekny
3. J. Burda
4. Beth Stevens
5. M. Pekna
6. B. Barres
7. Alexei Verkhratsky
8. C. Eroglu

In Neurology

1. M. Sofroniew
2. B. Barres
3. M. Pekny
4. Beth Stevens
5. R. Ransohoff
6. J. Burda
7. M. Pekna
8. Alexei Verkhratsky

Citations in the corpus

• Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner (2012, positive): “) (Stevens et al., 2007), suggesting the intriguing possibility that complement cascade activation and function is regulated by neural activity.”
• Microglia Function in the Central Nervous System During Health and Neurodegeneration (2017, background): “Two proteins of the complement cascade, C1q and C3, tag unused synapses for microglia recognition via complement receptor 3 (CR3; a heterodimer of CD11b and CD18), or for direct lysis via the complement cascade (68, 69) (Figure 2).”
• The semantics of microglia activation: neuroinflammation, homeostasis, and stress (2021, background): “showed that inactive projections from retinal ganglion cells (RGC) in the dorsal lateral geniculate nucleus (dLGN) were pruned in a complement-dependent manner [98].”
• Mechanisms underlying development of visual maps and receptive fields. (2008, background): “Components of the classical complement cascade of immune proteins are expressed at developing retinogeniculate synapses, and in their absence, much of the normal synaptic elimination that occurs during fine-scale retinotopic refinement is prevented (Stevens et al. 2007).”
• The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain (2018, background): “Interestingly, C3, a part of the classical complement cascade required for synapse elimination (Stevens et al., 2007), is strongly upregulated in aging astrocytes in all brain regions examined, as are other members of the complement cascade (see below) (Figure 4F).”
• The Role of Microglia in the Healthy Brain (2011, background): “…© 2011 the authors 0270-6474/11/3116064-06$15.00/0 strengthening of the remaining synapses in the correct eyespecific region of the dorsal lateral geniculate nucleus (dLGN) (Campbell and Shatz, 1992; Jaubert-Miazza et al., 2005; Hooks and Chen, 2006; Stevens et al., 2007; Huberman et al., 2008).”
• Reactive Astrocytes: Production, Function, and Therapeutic Potential. (2017, background): “Given that A1s release many classical complement cascade components that can enhance synaptic degeneration (Stevens et al., 2007; Hong et al., 2016; Sekar et al., 2016) as well as a neurotoxin that induces the death of neurons and oligodendrocytes, this brings renewed focus to the potential…”