Regulation of noise in the expression of a single gene

By Ertugrul M. Ozbudak, Mukund Thattai, I. Kurtser, A. Grossman, Alexander van Oudenaarden. Nature Genetics, 2002

1,670 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/55f38f7958d95cca8c37baed3cdd30d6617a04cd

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Citations in the corpus

Stochastic gene expression and its consequences (2008, background): “Ozbudak et al. (2002) observed that variability in the expression of a gene expressing GFP driven by an inducible promoter in B. subtilis depended on the underlying biochemical rates of transcription and translation.”
Identifying global regulators in transcriptional regulatory networks in bacteria. (2003, background): “The armament for our understanding of regulatory networks, co-regulated groups, clusters and their overlapping genes, has recently increased beyond the operons, regulons and stimulons, to structurally and computationally defined motifs and modules of the network [50 ,60 ,61 ], with dynamical propert”
Introduction to systems biology. (2007, background): “One successful approach of synthetic biology has been the analysis of noise [104–111].”
Real-time kinetics of gene activity in individual bacteria. (2005, background): “Thefirst quantitative study, using a single GFP reporter in Bacillus subtilis, interpreted the results in terms of small-number mRNA fluctuations and translation bursts (Ozbudak et al., 2002).”
Control, exploitation and tolerance of intracellular noise (2002, neutral): “As an experimental verification, van Oudenaarden and colleagues studied how the frequencies of transcription and translation contribute to variability in gene expression by measuring expression of a green fluorescent protein (GFP) marke”
Stochastic protein expression in individual cells at the single molecule level (2006, background): “We assume that: (1) distribution of protein molecules produced per expression event is exponential; (2) expression events are temporally uncorrelated; and (3) protein molecule copy numbers are halved at cell division.”
Cellular heterogeneity: when do differences make a difference? (2010, background): “Cellto-cell differences, for example those due to biochemical noise (Elowitz et al., 2002; Newman et al., 2006; Ozbudak et al., 2002; Raser and O’Shea, 2004), may have no functional significance.”
Robustness Can Evolve Gradually in Complex Regulatory Gene Networks with Varying Topology (2007, background): “The biochemical parameters that determine the behavior of cellular systems—from proteins to genome-scale regulatory networks—change continually. Such change has two principal sources. One of them is genetic and consists of mutations. The other is nongenetic; it is exemplified by noise internal to th”