A Genomic Regulatory Network for Development

By Eric H. Davidson, J. Rast, P. Oliveri, A. Ransick, C. Calestani, C. Yuh, T. Minokawa, G. Amore, V. Hinman, C. Arenas-Mena and 15 more. 2002

1,610 citations recorded by the source corpus.

Subfields: Molecular Biology

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Citations in the corpus

Robustness and fragility of Boolean models for genetic regulatory networks. (2005, methodology): “We propose a new modeling framework for gene regulatory networks, that combines the intuitive appeal ofa qualitative description of gene states with a high flexibility in incorporating stochasticity in the duration of cellular processes.”
Inferring cellular networks – a review (2007, background): “[88] test 10 algorithms, including Boolean and Bayesian networks, on a simulation [89] of the genetic network of the sea urchin embryo [90].”
Highly Conserved Non-Coding Sequences Are Associated with Vertebrate Development (2004, neutral): “The idea that animal development is controlled by cis-regulatory DNA elements (such as enhancers and silencers) is well established and has been elegantly described in invertebrates such as Drosophila and the sea urchin [ 1 ,2,3,4].”
GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. (2006, positive): “Efforts to understand luminal cell differentiation have focused on the estrogen receptor (ERa), which is found in asubsetofluminalcellsthatexhibitlowproliferation( Cheng etal.,2004 ).ERaisfoundinonlyhalfofmatureluminalcells and is found in fibroblasts and other stromal cells.”
The topology of the regulatory interactions predicts the expression pattern of the segment polarity genes in Drosophila melanogaster. (2003, methodology): “To investigate this, we propose and analyze a Boolean model of this network which is based on a binary ON/OFF representation of transcription and protein levels, and in which the interactions are formulated as logical functions.”