elife.elifesciences.org RESEARCH ARTICLE Convergence of pontine and

2013

207 citations recorded by the source corpus.

Cerebellar granule cells constitute the majority of neurons in the brain and are the primary conveyors of sensory and motor-related mossy fiber information to Purkinje cells. The functional capability of the cerebellum hinges on whether individual granule cells receive mossy fiber inputs from multiple precerebellar nuclei or are instead unimodal; this distinction is unresolved. Using cell-type-specific projection mapping with synaptic resolution, we observed the convergence of separate sensory (upper body proprioceptive) and basilar pontine pathways onto individual granule cells and mapped this convergence across cerebellar cortex. These findings inform the long-standing debate about the multimodality of mammalian granule cells and substantiate their associative capacity predicted in the Marr-Albus theory of cerebellar function. We also provide evidence that the convergent basilar pontine pathways carry corollary discharges from upper body motor cortical areas. Such merging of related corollary and sensory streams is a critical component of circuit models of predictive motor control. DOI: http://dx.doi.org/10.7554/eLife.00400.001

Subfields: Cognitive Neuroscience, Neurology

Citations in the corpus

• Re-evaluating circuit mechanisms underlying pattern separation (2019, neutral): “But, in the past decade, anatomical (Huang et al., 2013) and physiological evidence (Proville et al.”
• The Cerebellum, Sensitive Periods, and Autism (2014, background): “, 2013), where information from multiple sensory modalities can be integrated (Huang et al., 2013).”
• Morphological Constraints on Cerebellar Granule Cell Combinatorial Diversity (2017, background): “MF distributions from bulk-labeled nuclei show much denser innervation patterns (McCrea et al., 1977; Shinoda et al., 1992; Akintunde and Eisenman, 1994; Brodal and Bjaalie, 1997; Quy et al., 2011; Huang et al., 2013; Houck and Person, 2014, 2015).”
• Shared cortex-cerebellum dynamics in the execution and learning of a motor task (2019, unknown): “GrC anatomy is highly distinctive: each GrC receives only four inputs, called mossy fibers, which are fixed during development and can originate from neocortex via the pontine nuclei, as well as from the brainstem and spinal cord (Huang et al., 2013; Sillitoe et al., 2012).”
• Optimal degrees of synaptic connectivity (2017, unknown): “However, within defined spatial domains, inputs to individual granule cells appear heterogeneous (Huang et al., 2013; Chabrol et al., 2015; Ishikawa et al., 2015), supporting a spatially restricted form of randomness.”
• Computational Principles of Supervised Learning in the Cerebellum (2018, unknown): “Support for this idea comes from the demonstration that different mossy fiber streams converge onto individual granule cells (Chabrol et al. 2015, Huang et al. 2013, Ishikawa et al. 2015) (multimodal granule cell in Figure 2; see also Sawtell 2010), a process that would favor pattern separation…”
• Multimodal sensory integration in single cerebellar granule cells in vivo (2015, background): “DOI: 10.7554/eLife.12916 1 of 10 multisensory inputs (Azizi and Woodward, 1990; Huang et al., 2013).”