Shared cortex-cerebellum dynamics in the execution and learning of a motor task
By M. Wagner, Tony Hyun Kim, Jonathan Kadmon, Nghia D. Nguyen, Surya Ganguli, Mark J. Schnitzer, Liqun Luo. 2019
183 citations recorded by the source corpus.
SUMMARY Throughout mammalian neocortex, layer 5 pyramidal (L5) cells project via the pons to a vast number of cerebellar granule cells (GrCs), forming a fundamental pathway. Yet it is unknown how neuronal dynamics are transformed through the L5→GrC pathway. Here, by directly comparing premotor L5 and GrC activity during a forelimb movement task using dual-site two-photon Ca2+ imaging, we found that in expert mice, L5 and GrC dynamics were highly similar. L5 cells and GrCs shared a common set of task-encoding activity patterns, possessed similar diversity of responses, and exhibited high correlations comparable to local correlations among L5 cells. Chronic imaging revealed that these dynamics co-emerged in cortex and cerebellum over learning: as behavioral performance improved, initially dissimilar L5 cells and GrCs converged onto a shared, low-dimensional, task-encoding set of neural activity patterns. Thus, a key function of cortico-cerebellar communication is the propagation of shared dynamics that emerge during learning.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology
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Citations in the corpus
- Re-evaluating circuit mechanisms underlying pattern separation (2019, positive): “Similarly, a recent study in mice has found low-dimensional granule cell representations during a simple forelimb-movement task (Wagner et al., 2018).”