A general test of association for quantitative traits in nuclear families.

By Gonçalo R. Abecasis, Lon R. Cardon, W. Cookson. American Journal of Human Genetics, 2000

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Second-generation PLINK: rising to the challenge of larger and richer datasets (2014, methodology): “However, a comparison of statistical power is only meaningful if both procedures are anchored to the same Type 1 error rate with respect to the null hypothesis of no linkage with a causal variant, and Ewens et al. has shown that the QTDT is not robust against certain forms of confounding (population”
New approaches to population stratification in genome-wide association studies (2010, background): “) are immune to stratification, as transmitted and untransmitted alleles have the same genetic ancestr”
Genomewide Rapid Association Using Mixed Model and Regression: A Fast and Simple Method For Genomewide Pedigree-Based Quantitative Trait Loci Association Analysis (2007, methodology): “Table2showspower of different approaches to detect a QTL when using ﬁxed thresholds following a x 2d : f : ¼ 1 - distribution.”
DNA methylation age of blood predicts all-cause mortality in later life (2015, positive): “The model was fitted using QTDT [50].”
A unified mixed-model method for association mapping that accounts for multiple levels of relatedness (2006, methodology): “Family-based samples (area II) have been exploited to avoid the effect of population structur”
Interleukin 7 receptor α chain ( IL7R ) shows allelic and functional association with multiple sclerosis (2007, neutral): “A quantitative transmission disequilibrium test (QTDT) analysi”