The Meter of Metabolism

By Carla B. Green, Joseph S. Takahashi, Joseph Bass. Cell, 2008

873 citations recorded by the source corpus.

The circadian system orchestrates the temporal organization of many aspects of physiology, including metabolism, in synchrony with the 24 hr rotation of the Earth. Like the metabolic system, the circadian system is a complex feedback network that involves interactions between the central nervous system and peripheral tissues. Emerging evidence suggests that circadian regulation is intimately linked to metabolic homeostasis, and that dysregulation of circadian rhythms can contribute to disease. Conversely, metabolic signals also feed back into the circadian system, modulating circadian gene expression and behavior. Here, we review the relationship between the circadian and metabolic systems, and the implications for cardiovascular disease, obesity and diabetes.

Subfields: Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/5581e1866863e3839ce41508971fd110c46a16c2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. Till Roenneberg
2. C. Green
3. K. Allebrandt
4. M. Merrow
5. Céline Vetter
6. J. Takahashi
7. J. Mohawk
8. Ethan D. Buhr

In Physiology

1. C. Green
2. J. Takahashi
3. Till Roenneberg
4. Ethan D. Buhr
5. M. Merrow
6. Judith Y. Altarejos
7. M. Montminy
8. J. Mohawk

Citations in the corpus

• Social jetlag and obesity. (2012, positive): “The circadian clock also regulates energy homeostasis [16], and its disruption—as with social jetlag—may contribute to weight-related pathologies [17–19].”
• CREB and the CRTC co-activators: sensors for hormonal and metabolic signals (2011, positive): “In addition to being regulated by the effects of fasting and feeding hormones, hepatic gluconeogenesis is subject to regulation by the circadian clock, which coordinates hepatic metabolism with changes in the external environmen”
• Molecular components of the Mammalian circadian clock. (2013, positive): “disorders, circadian clocks are also directly linked with feeding and cellular metabolism, and a number of metabolic complications may result from miscommunication with the circadian clock and metabolic pathways (Green et al. 2008).”
• CENTRAL AND PERIPHERAL CIRCADIAN CLOCKS IN MAMMALS (2012, positive): “Circadian control of metabolism occurs at the central (SCN) as well as local levels and involves clocks within a number of peripheral tissues including the liver, pancreas, skeletal muscle, intestine, and adipose tissue (for a review, see Bass & Takahashi 2010, Green et al. 2008).”
• CircaDB: a database of mammalian circadian gene expression profiles (2012, neutral): “Circadian rhythms are biological rhythms of 24 h in many physiological and behavioral processes (1,2).”
• SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM (2012, neutral): “SIRT1 is expressed in the SCN, next to the ubiquitously expressed CLOCK, BMAL1, and all other components of the circadian machinery (119).”