Historical landmarks of autophagy research

By Y. Ohsumi. Cell Research, 2013

996 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Neuronal Cell Death. (2018, positive): “Autophagosome formation is initiated through a cascade of signals targeted at three distinct multi-protein complexes comprising autophagy-related (ATG) genes and additional proteins that are not homologs of the yeast ATG repertoire (519) but are found in multicellular organisms.”
Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria (2016, background): “A a cell survival pathway, autophagy selectively frees the cytosolic compartment from bulky protein aggregates, invading bacteria or damaged organelles such as mitochondria and peroxisomes (1, 2).”
Molecular mechanisms of cell death in neurological diseases (2021, background): “Autophagy is a highly conserved process for the degradation of macro-molecular structures and even entire organelles that plays critical roles in cellular and tissue homoeostasis [81].”
Autophagy during viral infection — a double-edged sword (2018, background): “The core components consist of more than 30 autophagy proteins (ATGs) 145 .”
Autophagy and autophagy-related proteins in cancer (2020, background): “So far, more than 40 genes encoding Atg proteins have been identified in yeast [49], and most of the genes (e.”