Complement Factor H Polymorphism and Age-Related Macular Degeneration

By A. Edwards, R. Ritter, K. Abel, A. Manning, Carolien I. M. Panhuysen, L. Farrer. Science, 2005

1,802 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Ophthalmology

View Paper: https://www.semanticscholar.org/paper/54cf7c48c4a84e522511b80619b9b790da8a527a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Steve Horvath
2. John P. A. Ioannidis
3. Aldons J. Lusis
4. John V. Forrester
5. I. Bhutto
6. Mei Chen
7. G. Lutty
8. Heping Xu

In Molecular Biology

1. John P. A. Ioannidis
2. Evangelos Evangelou
3. Gonçalo R. Abecasis
4. Eric E. Schadt
5. Steve Horvath
6. Aldons J. Lusis
7. David Clayton
8. Mark J. Daly

In Ophthalmology

1. Emily Y. Chew
2. Baljean Dhillon
3. I. Bhutto
4. G. Lutty
5. G. Hageman

Citations in the corpus

• Para-inflammation in the aging retina. (2009, background): “The resurgence of interest in the role of complement activation in agerelated retinal disease, in particular age-related macular degeneration, is largely attributable to the discovery of the link between complement factor H (CFH) polymorphisms and the risk of agerelated macular degeneration (Edwards”
• Variations in DNA elucidate molecular networks that cause disease (2008, methodology): “The fold enrichment is computed as the observed overlap count divided by the expected overlap count, estimated by multiplying the MEMN transcript count (1,406) by the fraction ‘gene set count divided by total gene count (23,574)’.”
• Overcoming the winner's curse: estimating penetrance parameters from case-control data. (2007, methodology): “To apply this algorithm to tests that do not have a simple method of power calculation, equation (4) can be evaluated by sampling conditional on v and f and approximating by Monte D Pr (BFv,f) i”
• The Pivotal Role of the Complement System in Aging and Age-related Macular Degeneration: Hypothesis Re-visited (2009, neutral): “…highly significant associations between AMD and sequence variants of several complement pathwayassociated genes including: Complement factor H (CFH) (Edwards et al., 2005; Hageman et al., 2005; Haines et al., 2005; Klein et al., 2005), complement factor B (CFB) and complement component 2 (C2)…”
• The Impact of Oxidative Stress and Inflammation on RPE Degeneration in Non-neovascular AMD (2017, background): “A decade ago, the discovery of polymorphisms in complement factor H (CFH) with up to a sevenfold increased risk of AMD introduced innate immunity as a pathophysiologic factor (Edwards et al., 2005; Hageman et al., 2005; Haines et al., 2005; Klein et al., 2005).”
• Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex (2012, methodology): “Using DNA sequence data from the Human Genome Project, three independent groups demonstrated that a polymorphism (Tyr402His) in the CFH gene increases the risk of developing AMD (Edwards et al., 2005; Haines et al., 2005; Klein et al., 2005b).”