The Ras superfamily at a glance
By Krister Wennerberg, K. Rossman, C. Der. Journal of Cell Science, 2005
1,557 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/53defa25f12ac505cf5766da515cafbba105a0b7
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In Cell Biology
In Molecular Biology
- Rodrigo Vargas Honorato
- C. Der
- K. Rossman
- J. Cherfils
- Tatu Pantsar
- Alexandre M. J. J. Bonvin
- Arnold M. Saxton
- Xiaofei Wang
In Physiology
Citations in the corpus
- GEFs and GAPs: critical elements in the control of small G proteins. (2007, background): “The human Ras superfamily consists of at least 154 members divided into five principal families: the Ras, Rho, Rab, Arf, and Ran families (Wennerberg et al., 2005).”
- Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development (2020, background): “More than 150 members belong to the Ras superfamily of small guanosine triphosphatases (GTPases) [95].”
- Reactive Oxygen Species in Inflammation and Tissue Injury (2014, neutral): “However, Rac1 and Cdc42 are required for the assembly and maturation of endothelial junctions, and their activity increases during junction formation (144, 226, 234, 449).”
- Manipulation of thyroid status and/or GH injection alters hepatic gene expression in the juvenile chicken (2007, background): “, the ra s -related C 3 botulinum toxin substrate 1 (Rac), Rho and CDC42 subfamilies) represent signaling molecules that are activated by a diversity of growth factors, cytokines, hormones, G-proteins and cell adhesion proteins (Jaffe and Hall, 2005; Wennerberg et al., 2005).”
- Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies (2023, background): “70 RAS is extremely prevalent, as RAS mutations are detected in approximately 30% of all tumors.”
- Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? (2010, background): “Two other RhoGEFs have been described (SWAP70 and SLAT) contain a PH but no DH domain (2) and smgGDS (1) is an unusual GEF in that it functions as a GEF for some Rho as well as non-Rho family GTPases.”