Complete mutagenesis of the HIV-1 protease

By D. Loeb, R. Swanstrom, L. Everitt, M. Manchester, S. E. Stamper, C. Hutchison. 1989

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Citations in the corpus

SNAP: predict effect of non-synonymous polymorphisms on function (2007, unknown): “These were the mutagenesis data for LacI repressor from Escherichia coli (32), bacteriophage T4 lysozyme (33), and HIV-1 protease (34).”
News from the protein mutability landscape. (2013, background): “[60] Loeb DD, Swanstrom R, Everitt L, Manchester M, Stamper SE, Hutchison CA.”
Needles in stacks of needles: finding disease-causal variants in a wealth of genomic data (2011, unknown): “One such source is mutagenesis experiments of individual proteins that generate many possible mutations and assess their function, as has been performed for several bacterial and viral proteins 95–97 .”
Evolvability as a function of purifying selection in TEM-1 β-lactamase. (2015, unknown): “The tolerance of many proteins to mutations has been assessed in a number of important studies with high-throughput site-directed and random mutagenesis (Fowler et al., 2010; Guo et al., 2004; Huang et al., 1996; Jacquier et al., 2013; Loeb et al., 1989; McLaughlin et al., 2012; Melnikov et al., 201”
Predicting deleterious amino acid substitutions. (2001, methodology): “Out of 215 substitutions predicted by SIFT to be deleterious deleterious, 85% give an affected phenotype (Table 1, experimental prediction accuracy) using the protease assay by Loeb et al. (1989).”
Alteration of Substrate and Inhibitor Specificity of Feline Immunodeficiency Virus Protease (2000, background): “However, the corresponding G48 residue of HIV-1 protease was shown to be tolerant to substitution with Ile or His (24, 36).”
Evidence of HIV-1 Adaptation to HLA-Restricted Immune Responses at a Population Level (2002, background): “This has some merit given that both RT and protease are relatively conserved proteins, and protease is only 99 amino acids long.(793) However, both proteins appear to be able to”