Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

By Ok-hee Jeon, Chaekyun Kim, Rémi-Martin Laberge, M. Demaria, Sona Rathod, A. Vasserot, Jae Wook Chung, Do Hun Kim, Yan Poon, Nathaniel E. David and 4 more. Nature Medicine, 2017

1,334 citations recorded by the source corpus.

Subfields: Cancer Research, Microbiology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/53c54ba96c49cd92f21d4da0aa26a80dd0322f36

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Jun Guo
2. Xiuqing Huang
3. A. Alimonti
4. Linli Zheng
5. A. Calcinotto
6. L. Dou
7. Mingjing Yan
8. Ziji Zhang

Citations in the corpus

• Aging and aging-related diseases: from molecular mechanisms to interventions and treatments (2022, background): “In one mouse model, injection of UBX0101 selectively eliminated senescent cells and reduced proteoglycan loss, which alleviated the cartilage degradation and pain caused by OA.339 Fenofibrate, a PPARα agonist, clears SAβ-gal-positive chondrocytes by promoting apoptosis.595 Fisetin, a flavonoid drug,”
• Cellular Senescence: Aging, Cancer, and Injury. (2019, background): “Therefore, therapies which selectively eliminate senescent cells may be effective to both prevent and treat osteoarthritis (167).”
• The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis. (2020, background): “metabolic alterations, and senescence, and all of these factors are also known as stressors (Bierma-Zeinstra and van Middelkoop, 2017; Courties et al., 2017; Jeon et al., 2017; Scanzello, 2017).”