Regulation of myostatin activity and muscle growth

By Se-Jin Lee, A. Mcpherron. Proceedings of the National Academy of Sciences of the United States of America, 2001

1,660 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/53bbc0e9a69a2d7138e754d47ed4d344c9768aa4

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Citations in the corpus

Cellular and molecular regulation of muscle regeneration. (2004, background): “A recent study suggests that MSTN signaling may be achieved by binding to activin type II receptors, particularly Act RIIB (186).”
Cellular and molecular mechanisms of muscle atrophy (2013, background): “…Muscle-specific transgenic Moderate muscle atrophy in males Reisz-Porszasz et al., 2003 ActRIIB Muscle-specific dominant negative Muscle hypertrophy Lee and McPherron, 2001 Follistatin Muscle-specific transgenic Muscle hypertrophy Lee and McPherron, 2001 Myostatin + FLRG specific FLRG transgenic…”
Specificity, versatility and control of TGF-β family signaling (2019, background): “When expressed in transfected cells, myostatin (also known as GDF8) and GDF11 are also secreted as latent complexes, in which the propolypepide association prevents mature ligand from binding and activating the receptors (19, 41).”
Functional improvement of dystrophic muscle by myostatin blockade (2002, background): “Alterations in Smad 2 and 3 phosphorylation would be predicted to regulate the formation of Smad complexes, their nuclear translocation and transcriptional regulation of genes associated with commitment of muscle progenitor”
Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival. (2010, background): “Expression of a dominant negative ActRIIB in transgenic mice results in skeletal muscle hypertrophy, suggesting an important role of ActRIIB pathway in limiting muscle growth (Lee & McPherron, 2001).”
Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis (2003, result): “In addition, we observed the previously reported (27) weak binding of [(125)I]myostatin to ActRII; however, this was detected only when ActRII was expressed at levels 10-fold higher than those of ActRIIB in transfected cells (data not shown).”
Exercise is the real polypill. (2013, background): “Although myostatin increases might contribute to insulin resistance (184, 360), obesity (185), muscle wasting (63, 70, 97, 154), or agingsarcopenia (523), its loss/inhibition decreases adiposity (164, 303, 521, 530), induces browning of the white adipose tissue [through AMPK-peroxisome proliferator-”
Zebrafish as a model organism for nutrition and growth: towards comparative studies of nutritional genomics applied to aquacultured fishes (2011, background): “Previous studies in mammals have demonstrated that myostatin is binds to the two activin type II receptors (ActRII) (Lee and McPherron 2001; Rebbapragada et al. 2003).”