SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

By N. Le Bert, A. Tan, Kamini Kunasegaran, C. Tham, Morteza Hafezi, A. Chia, M. Chng, Meiyin Lin, N. Tan, M. Linster and 9 more. Nature, 2020

1,872 citations recorded by the source corpus.

Subfields: Infectious Diseases, Neurology

View Paper: https://www.semanticscholar.org/paper/53a40cf0f2d18ca0cdc8392d34e0bdeda12f8b3b

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In Infectious Diseases

1. Kwok-Yung Yuen
2. K. To
3. V. Cheng
4. Kwok-Hung Chan
5. Alessandro Sette
6. Shane Crotty
7. Shuofeng Yuan
8. F. Krammer

In Neurology

1. Shane Crotty

Citations in the corpus

• Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19 (2020, background): “Furthermore, T cells responding to these antigens may be more cross-reactive[18].”
• Adaptive immunity to SARS-CoV-2 and COVID-19 (2021, background): “Spike, M, and nucleocapsid are the most prominent targets of SARS-CoV-2-specific CD4+ T cells (Grifoni et al., 2020), with substantial responses also against ORF3a and nsp3 (Le Bert et al., 2020; Grifoni et al., 2020; Nelde et al., 2021; Oja et al., 2020; Peng et al., 2020).”
• COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirmed by whole genome sequencing (2020, background): “Studies with coronaviruses before the COVID-19 pandemic showed that coronaviruses can induce long-lasting T cell immunity [31].”
• Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients (2021, background): “…components (Long et al., 2020a; Gudbjartsson et al., 2020; Sun et al., 2020) and cellular components (Grifoni et al., 2020; Braun et al., 2020; Le Bert et al., 2020; Weiskopf et al., 2020) of adaptive immunity are induced in SARS-CoV-2-infected individuals, but their roles in viral control or…”
• Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity (2021, positive): “Even in the absence of neutralizing humoral immunity, previous studies have suggested that cellular immunity can mitigate severe or prolonged infection (Le Bert et al., 2020).”
• Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection (2021, positive): “Using different approaches, studies determined the long-term durability of memory CD4 T cells to smallpox, over a period of many years, to be an estimated t1/2 of ~10 years (61, 64), which is also consistentwith recent detection of SARS-CoV-specific T cells 17 years after the initial infection (65).”