Exploiting senescence for the treatment of cancer

By Liqin Wang, L. Lankhorst, René Bernards. Nature Reviews. Cancer, 2022

691 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/537b124e90cf0e924a183a6b4453561d9b98cdc6

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Citations in the corpus

• Aging and aging-related diseases: from molecular mechanisms to interventions and treatments (2022, methodology): “Senolytic agents can selectively eliminate senescent cells and minimize side effect of senescence-inducing therapy.(486) Antiapoptotic BCL-2 family proteins (BCL-2, BCL-XL, and BCL-W) are therapeutic targets for eliminating senescent tumor cells.”
• Immunosenescence: molecular mechanisms and diseases (2023, background): “Senescent cells that regain stemness acquire increased proliferative capacity and tumorigenesis potential.(167,196) In summary, the role of senescent T cells in the growth, invasion, and resistance to therapies for immunosenescence and agerelated diseases remains questionable.”