Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides.

By Bhawna Gupta, T. S. Levchenko, Vladimir Torchilin. Advanced Drug Delivery Reviews, 2005

657 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5312007b9e7d435250b9ddcb35881aedb5234529

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. N. Desai

In Molecular Biology

1. L. Rajendran
2. Maria Laura Immordino
3. S. Y. Ng
4. A. Lee
5. Cherine Bechara
6. H. Knölker
7. N. Desai
8. S. Sagan

Citations in the corpus

• Subcellular targeting strategies for drug design and delivery (2010, background): “Direct transport of cargo across the plasma membrane can be achieved by conjugating molecules to CPP”
• Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential (2006, background): “International Journal of Nanomedicine 2006:1(3)310 TATp-liposomes-DNA complexes were found to be capable of transfection of both normal and cancer cells in vitro and in vivo with lower cytotoxicity that the commonly used lipidbased gene delivery systems (Gupta et al 2005).”
• Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery (2006, background): “A class of cationic peptides, the PTDs, such as the TAT, penetratin, and VP22 peptides, may have the ability to be taken up by cells without endocytosis events (Vives et al., 1997; Thoren et al., 2003; Nakase et al., 2004; Brooks et al., 2005; Gupta et al., 2005).”
• Cell‐penetrating peptides: 20 years later, where do we stand? (2013, background): “CPPs can transport inside living cells a variety of covalently or non-covalently linked cargoes, as has been reviewed for nanoparticles [18], peptides [18,19], proteins [20,21], antisense oligonucleotides [20,22], small interfering RNA [23], double stranded DNA [18] and liposomes [18].”
• Challenges in Development of Nanoparticle-Based Therapeutics (2012, background): “arginine and TAT, enable the uptake of agents that otherwise cannot effectively enter cancer cells (18).”
• Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets (2019, background): “Different unique properties and nature of these CPPs allow non-invasive internalization of conjugated peptides or small molecules through the plasma membrane (Gupta et al., 2005; Foged and Nielsen, 2008).”