Microglia Biology: One Century of Evolving Concepts.

By Marco Prinz, Steffen Jung, Josef Priller. Cell, 2019

1,245 citations recorded by the source corpus.

Microglia were first recognized as a distinct cell population in the CNS one century ago. For a long time, they were primarily considered to be phagocytes responsible for removing debris during CNS development and disease. More recently, advances in imaging and genetics and the advent of single-cell technologies provided new insights into the much more complex and fascinating biology of microglia. The ontogeny of microglia was identified, and their functions in health and disease were better defined. Although many questions about microglia and their roles in human diseases remain unanswered, the prospect of targeting microglia for the treatment of neurological and psychiatric disorders is tantalizing.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/52efc889a1357872f90acf538f5cc97a61a7e4eb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Michael A. Wheeler
2. M. Linnerbauer
3. F. Quintana

In Neurology

1. F. Quintana
2. M. Linnerbauer
3. Michael A. Wheeler

Citations in the corpus

• Astrocyte crosstalk in CNS inflammation (2020, background): “Indeed, Argaw and colleagues (2012) demonstrated that VEGF-A production in astrocytes is upregulated in response to IL-1β, a cytokine produced by activated microglia during neuroinflammation (Liddelow et al., 2017; Prinz et al., 2019; Wheeler et al., 2020b).”