Disturbed mitochondrial dynamics and neurodegenerative disorders

By F. Burté, V. Carelli, Patrick F. Chinnery, P. Yu‐Wai‐Man. Nature Reviews Neurology, 2015

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Mitochondrial dynamics in health and disease: mechanisms and potential targets (2023, background): “51,66 Early embryonic lethality are observed in double knockout or OPA1 mutant mice.”
Measuring in vivo mitophagy (2015, background): “There is growing interest in the potential role of mitophagy in aging and age-related conditions (Burté et al., 2015; Madeo et al., 2015).”
Mitophagy and Alzheimer’s disease: cellular and molecular mechanisms (2017, background): “Prior to fission, damaged DNA and proteins are segregated to one side of the mitochondrion such that upon fission one of the ‘daughter’ mitochondrion contains damaged molecules and is targeted for mitophagy, while the other daughter mitochondrion is now pristine [10, 76].”
Mitochondria-lysosome contacts regulate mitochondrial fission via Rab7 GTP hydrolysis (2018, positive): “Thus, future studies examining additional roles and protein tethers involved at these contacts will provide valuable insight into cellular organization and the pathogenesis of multiple diseases linked to both mitochondrial and lysosomal dysfunction 2–4”