Poly(ethylene oxide)-block-poly(L-amino acid) micelles for drug delivery.

By A. Lavasanifar, J. Samuel, G. Kwon. Advanced Drug Delivery Reviews, 2002

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Intelligent polymeric micelles from functional poly(ethylene glycol)-poly(amino acid) block copolymers. (2009, background): “Although any types of amphiphilic block copolymers could form micelle structure, extensive studies have shown that poly(ethylene glycol)-poly(amino acids) (PEG-PAA) block copolymers are possibly themost facile components to design the polymeric micelles [22].”
Role of nanotechnology in targeted drug delivery and imaging: a concise review. (2005, background): “Micelle-forming block copolymers of poly(amino acid)-drug conjugates have also been formed and studied [131-133]; however, this involved chemical modification of the drug.”
Block copolymer micelles: preparation, characterization and application in drug delivery. (2005, background): “By varying the chemical structure of PAA, it is possible to tailor their enzymatic degradability and degree of immunogenicity [6].”
A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics (2012, positive): “Their hydrophilic surface characteristics also shield them from immediate recognition and subsequently increase circulation time (Lavasanifar et al., 2002).”