TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains?

By E. Winter, Chris P. Ponting. 2002

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Accurate prediction of protein structures and interactions using a 3-track neural network (2021, positive): “The RoseTTAFold CERS1 model for residues 98 to 304 (Pfam TLC domain) (29) includes six TMH that traverse the membrane in an up and down arrangement (Fig.”
Mammalian Ceramide Synthases (2010, background): “Subsequent bioinformatics analyses (13, 17, 18) revealed additional mammalian Lag homologs, originally characterized as translocating chain-associating membrane protein homologs (TRH) (8, 10), with the ceramides synthesized”
Molecular Cloning, Characterisation and Tissue-specific Expression of Human LAG3, a Member of the Novel Lag1 Protein Family (2003, background): “Most of the homologue proteins share a similar profile of six or seven transmembrane helices, a basic domain between the first two helices on the amino terminus, a Lag1 motif of 52 amino acids and a carboxyl-terminal acidic domain (Jiang et al., 1998; Winter and Ponting, 2002).”