Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women.

By S. Adams, C. Hoppel, Kerry H. Lok, Ling Zhao, S. Wong, P. Minkler, Daniel H. Hwang, J. Newman, W. Garvey. Journal of NutriLife, 2009

598 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/4170787bae5472759cffb1b6dbde718b757b9379

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Max C. Petersen
2. Gerald I. Shulman
3. Thomas Illig
4. Jerzy Adamski
5. R. Wanders
6. Ralph DeFronzo

In Physiology

1. Max C. Petersen
2. F. B. Hu
3. M. Schulze
4. A. Hruby
5. M. Roden
6. Gerald I. Shulman
7. Sander M. Houten
8. R. Wanders

Citations in the corpus

• Mechanisms of Insulin Action and Insulin Resistance. (2018, background): “This dissociation of muscle and plasma acylcarnitine profiles, also reported in humans (784), indicates that plasma acylcarnitines probably cannot be used to interrogate incomplete FAO in skeletal muscle, although several groups have attempted to do so (5, 541).”
• Metabolomics in Prediabetes and Diabetes: A Systematic Review and Meta-analysis (2016, background): “Medium-chain acylcarnitines C6-carnitine, C8-carnitine, and C10-carnitine were higher and propionylcarnitine concentrations were lower in participants with diabetes compared with nondiabetic control subjects (38).”
• Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach (2013, result): “The results agree with data from cross-sectional studies showing that patientswith T2D had increased concentrations of sugar metabolites (13), acylcarnitines (14), and BCAA (13) and reduced concentrations of glycine (12).”
• Increased Levels of Plasma Acylcarnitines in Obesity and Type 2 Diabetes and Identification of a Marker of Glucolipotoxicity (2010, unknown): “Two recent human studies comparing AcylCN patterns in lean and obese (21) or obese individuals with or without T2DM (22) observed some of the same patterns we observed in this study.”
• A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation (2010, background): “The elevation of free carnitine and, thereby, promotion of the export of acylcarnitines is proposed as a novel therapeutic approach (Koves et al. 2008; Noland et al. 2009; Mynatt 2009; Adams et al. 2009).”