A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21

By Ian Tomlinson, E. Webb, L. Carvajal-Carmona, P. Broderick, Z. Kemp, S. Spain, S. Penegar, I. Chandler, M. Gorman, Wendy Wood and 22 more. Nature Genetics, 2007

837 citations recorded by the source corpus.

Subfields: Genetics, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/525e9b13430dbe83425750df3a60afbc491918aa

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In Genetics

1. Elizabeth T. Cirulli
2. George A. Calin
3. Stefan Schreiber
4. David B. Goldstein
5. Greg Gibson

In Oncology

1. George A. Calin
2. Sendurai A Mani
3. Ian Tomlinson

Citations in the corpus

• Sequence variants at the TERT- CLPTM1L locus associate with many cancer types (2009, neutral): “prostate cancer variants has been shown also to associate with risk of another cancer; colorectal cancer 7 .”
• CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer (2013, methodology): “The British CRC samples were derived from a set of CRC patients recruited as part of the CORGI study who had known genotypes at the 8q24 tagSNP (Tomlinson et al. 2007).”
• Common and rare variants in multifactorial susceptibility to common diseases (2008, background): “The problem of identifying the functional variant is well illustrated by the extensive studies on the undoubtedly significant association of SNPs at 8q24 with both colorectal and prostate cance”
• Uncovering the roles of rare variants in common disease through whole-genome sequencing (2010, background): “For example, when associated SNPs are far from the nearest gene, it is often assumed that a regulatory variant of subtle effect must be the cause, such as for the SNPs in 8q24 that are associated with colorectal cance”
• STrengthening the REporting of Genetic Association Studies (STREGA)— An Extension of the STROBE Statement (2009, neutral): “org 0158 February 2009 | Volume 6 | Issue 2 | e1000022 association studies [85,87–105].”
• Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer (2008, background): “Recent GWA studies have validated the hypothesis that part of the heritable risk is caused by common, low-risk variants, identifying CRC susceptibility loci mapping to 8q24 (rs6983267”