Ras and Rho GTPases: a family reunion.

By D. Bar-Sagi, Alan Hall. Cell, 2000

843 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5240b4546298f08e0e3b1321dbe0356ad7fe72ca

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Citations in the corpus

Epithelial-mesenchymal transition and its implications for fibrosis. (2003, positive): “This conversion of epithelia is dependent on molecular switches under the control of the Ras superfamily of small GTPases (71).”
Activation of Rac and Cdc42 Video Imaged by Fluorescent Resonance Energy Transfer-Based Single-Molecule Probes in the Membrane of Living Cells (2002, neutral): “Among them, Rho family G proteins, including Rho, Rac, and Cdc42, are involved in the regulation of a variety of cellular processes, probably through actin cytoskeleton reorganization (1, 9, 13, 48).”
Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool‐2/α‐Pix (2004, positive): “…that result in changes in the actin cytoskeletal architecture, the stimulation of cell cycle progression and gene transcription, and the regulation of intracellular trafficking activities (Van Aelst and D’Souza-Schorey, 1997; Hall, 1998; Bar-Sagi and Hall, 2000; Erickson and Cerione, 2001).”
p21-activated kinases in cancer (2006, neutral): “These proteins have distinct and specific cellular functions that are different from those of Ras and have been predominantly implicated in cytoskeletal reorganization and motility, as well as the production of reactive oxygen species (ROS”
The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis (2001, neutral): “RhoGEF is a well-known GEF for Rho/Rac/cdc42–type GTPases involved in signaling of cell growth, motility and related activitie”
Rac and Rho GTPases in cancer cell motility control (2010, neutral): “As a consequence of the large number of key functions assigned to Rho proteins, like proliferation, apoptosis/ survival, cell polarity, cell adhesion and plasticity of cell migration [99,100], it is not surprising that they play important roles in tumor biology [101].”
The deaf and the dumb: the biology of ErbB-2 and ErbB-3. (2003, positive): “Remarkably, it appears that the heterodimers avoid coupling to Grb2 and the Ras-specific GTPase-activating protein (Ras-GAP; [82]), effectors that can also negatively regulate mitogenic signals [83,84].”
Regulation of Dendritic Morphogenesis by Ras–PI3K–Akt–mTOR and Ras–MAPK Signaling Pathways (2005, neutral): “It is well known that Ras can cross-talk with other small GTPases, including Rho/Rac/CDC42 (Bar-Sagi and Hall, 2000).”