The genome sequence of the rice blast fungus Magnaporthe grisea

By R. Dean, Nicholas J. Talbot, D. Ebbole, M. Farman, T. Mitchell, M. Orbach, M. Thon, R. Kulkarni, Jin-Rong Xu, Huaqin Pan and 25 more. Nature, 2005

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Magnaporthe grisea is the most destructive pathogen of rice worldwide and the principal model organism for elucidating the molecular basis of fungal disease of plants. Here, we report the draft sequence of the M. grisea genome. Analysis of the gene set provides an insight into the adaptations required by a fungus to cause disease. The genome encodes a large and diverse set of secreted proteins, including those defined by unusual carbohydrate-binding domains. This fungus also possesses an expanded family of G-protein-coupled receptors, several new virulence-associated genes and large suites of enzymes involved in secondary metabolism. Consistent with a role in fungal pathogenesis, the expression of several of these genes is upregulated during the early stages of infection-related development. The M. grisea genome has been subject to invasion and proliferation of active transposable elements, reflecting the clonal nature of this fungus imposed by widespread rice cultivation.

Subfields: Molecular Biology, Pharmacology, Plant Science

View Paper: https://www.semanticscholar.org/paper/523c4ea5868967316502335da0ecb44bccd69702

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Citations in the corpus

Advanced methods of plant disease detection. A review (2014, neutral): “For example, enough rice to feed the entire population of Italy is destroyed by rice blast disease every year (Dean et al. 2005).”
Plant innate immunity in rice: a defense against pathogen infection (2016, background): “Pathogen Rice yield loss References Fungal disease Rice blast Magnaporthe oryzae Up to 100% [12] Rice sheath blight Rhizoctonia solani Up to 50% [8] False smut Ustilaginoidia virens (Cooke) Takah Up to 44% http://www.”
Comparative genome sequence analysis underscores mycoparasitism as the ancestral life style of Trichoderma (2011, background): “As with plant pathogenic fungi [27,28], we have also observed an expansion of plant cell wall degrading enzyme gene families.”
Poplar and Pathogen Interactions: Insights from Populus Genome-Wide Analyses of Resistance and Defense Gene Families and Gene Expression Profiling (2009, background): “As an obligate biotroph, M. larici-populina is not easily cultured and studied in a laboratory setting, unlike other model leaf fungal pathogens such as M. grisea and Ustilago maydis (Dean et al., 2005; Kämper et al., 2006).”