Tissue-specific dysregulation of cortisol metabolism in human obesity.
By E. Rask, T. Olsson, S. Söderberg, R. Andrew, D. Livingstone, Owe Johnson, B. Walker. Journal of Clinical Endocrinology and Metabolism, 2001
714 citations recorded by the source corpus.
Subfields: Behavioral Neuroscience, Endocrinology, Diabetes and Metabolism
View Paper: https://www.semanticscholar.org/paper/52344472900cb9d4df4cf744de48163eafd1d978
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Citations in the corpus
- Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. (2004, background): “The effect of weight loss on free and total testosterone and SHBG has been inconsistent, but overall or abdominal obesity increases glucocorticoid turnover and production (11,12), resulting in abnormal control of hypothalamic-pituitary-adrenal axis and possibly mild hypoandrogenism in men.”
- Clinical review: The pathogenetic role of cortisol in the metabolic syndrome: a hypothesis. (2009, background): “In humans, peroxisome proliferator-activated receptor (PPAR)- agonists used as antidiabetic drugs (known as thiazolidinediones) appear to inhibit the transcriptional activity of 11 -HSD1 in adipose tissue and to decrease the tissue-specific concentration of glucocorticoids (110, 122, 127).”
- Mechanisms of obesity-associated insulin resistance: many choices on the menu. (2007, background): “…suggesting that increases in endogenous 11 -HSD1 that have been observed in adipose tissue of obese humans and rodents (Livingstone et al. 2000; Rask et al. 2001; Paulmyer-Lacroix et al. 2002) contribute to obesity-associated insulin resistance, in part due to increased delivery of…”
- Fructose, weight gain, and the insulin resistance syndrome. (2002, background): “146) is increased in the adipose tissue of obese humans (12).”
- Pathogenesis of Type 2 Diabetes Mellitus (2015, background): “This could have the same effect in human[46] suggesting that increases in endogenous 11β-HSD1 in the adipose tissue of obese humans and rodents [47,48] contribute to obesity-associated IR, in part due to increased delivery of glucocorticoids to the liver via the portal vein.”
- 11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action. (2013, background): “Thus the ratio correlates positively (24), negatively (574), and not at all (23, 762) with obesity.”