Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men.
By D. Laaksonen, L. Niskanen, K. Punnonen, K. Nyyssönen, T. Tuomainen, Veli-Pekka Valkonen, R. Salonen, J. Salonen. Diabetes Care, 2004
931 citations recorded by the source corpus.
Subfields: Endocrinology, Diabetes and Metabolism, Experimental and Cognitive Psychology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/6e5991bfe3e9d5d33a82770312b2a5373dd18f5d
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In Endocrinology, Diabetes and Metabolism
Citations in the corpus
- Low serum testosterone and mortality in older men. (2008, background): “We, and others, have shown that low testosterone precedes the development of central obesity (24, 25), the metabolic syndrome (26, 27), and diabetes (6, 27, 28) over the following 10–15 yr in nonobese men without these conditions at baseline.”
- Estrogen-gut microbiome axis: Physiological and clinical implications. (2017, background): “Most conjugated estrogen is bound via a glycoprotein sex hormone binding globulin (SHBG) produced by the liver [10] with low SHBG levels being implicated in the development of metabolic syndrome [11].”
- Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. (2006, background): “Additionally, studies suggest that levels of testosterone are also associated with the metabolic syndrome in a similarly sex-divergent manner.(26,49,81,82) The observed sex-dimorphic associations between these hormonal biomarkers and type 2 diabetes may be explained by multiple pathways.”