Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis

By G. Clifford, Jennifer S. Smith, Martyn Plummer, N. Muñoz, Silvia Franceschi. British Journal of Cancer, 2003

1,749 citations recorded by the source corpus.

This study investigated regional variations in the contribution made by different human papilloma (HPV) types to invasive cervical cancer (ICC). A total of 85 studies using polymerase chain reaction to estimate HPV prevalence in ICC were identified. Data on HPV prevalence were extracted separately for squamous cell carcinoma (SCC) and for adeno- and adenosquamous-carcinoma (ADC). A total of 10 058 cases (8550 SCC, 1508 ADC) were included in pooled analyses. The most common HPV types in ICC were, in order of decreasing prevalence, HPV16, 18, 45, 31, 33, 58, 52, 35, 59, 56, 6, 51, 68, 39, 82, 73, 66 and 70. In SCC, HPV16 was the predominant type (46–63%) followed by HPV18 (10–14%), 45 (2–8%), 31 (2–7%) and 33 (3–5%) in all regions except Asia, where HPV types 58 (6%) and 52 (4%) were more frequently identified. In ADC, HPV prevalence was significantly lower (76.4%) than in SCC (87.3%), and HPV18 was the predominant type in every region (37–41%), followed by 16 (26–36%) and 45 (5–7%). The overall detection of HPV DNA was similar in different regions (83–89%). A majority of ICC was associated with HPV16 or 18 in all regions, but approximately a quarter of all ICC cases were associated with one of 16 other HPV types, their distribution varying by region.

Subfields: Epidemiology, Obstetrics and Gynecology, Reproductive Medicine

View Paper: https://www.semanticscholar.org/paper/5218649c0e4f7b886d41fd8b6877b9935fd76b33

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Silvia Franceschi
2. G. Clifford
3. B. Kasiske
4. D. Hanahan

In Obstetrics and Gynecology

1. G. Clifford
2. Silvia Franceschi

In Reproductive Medicine

1. Silvia Franceschi
2. G. Clifford

Citations in the corpus

• Cancer after Kidney Transplantation in the United States (2004, background): “There is increasing evidence that viruses may play an important role in the pathogenesis of skin cancers (18,19), cervical carcinomas (20,21), Kaposi’s sarcomas (22,23), hepatobiliary tumors (24,25), and lymphomas (26,27).”
• Human papillomavirus type distribution in invasive cervical cancer and high‐grade cervical lesions: A meta‐analysis update (2007, background): “–2Country not previously represented with ICC cases in Clifford et al., 2003 [ref.”
• Human Papillomavirus Types in Head and Neck Squamous Cell Carcinomas Worldwide: A Systematic Review (2005, background): “HPV18 has a special tropism for glandular tissue and is the most frequently detected type in adenocarcinomas of the cervix (14).”
• iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “The Working Group excluded from consideration high-grade precancerous lesions (CIN3 and the more equivocal CIN2 which occur in approximately 1% of screened women) often used as ethical surrogate end-points in prospective studies and clinical trials, because there are now enough data for invasive can”
• Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: A meta‐analysis (2009, methodology): “Methods for estimation of type-specific HPV prevalence have been described in detail previously.(24) Whereas most studies did report the prevalence of HPV16, the prevalence of other types was less frequently reported.”
• Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: Variation by geographical region, histological type and year of publication (2011, background): “In a recent working group at IARC, other types in the high-risk clade (HPV26, 30, 34, 53, 66, 67, 69, 70, 73, 82 and 85) were all classified for cautionary reasons as possibly carcinogenic to humans (Group 2B) even in the absence of adequate epidemiological data on their carcinogenic potential.5,9 O”
• An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis. (2004, background): “Introduction Cervical cancer is the second most common malignant disease among women worldwide (1), and the “high-risk” human papillomavirus (HPV) types, such as HPV-16 and HPV-18, are found in 80–90% of invasive cervical cancers as well as in distinctive premalignant stages (2) of cervical intraepi”