Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase.

By I. Waizenegger, Silke Hauf, A. Meinke, J. Peters. Cell, 2000

788 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/51fffe1eb5b8e9a4af21be2d3fa7a0ceff332a8d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Kim Nasmyth
2. C. Haering
3. J. Peters

In Molecular Biology

1. Kim Nasmyth
2. C. Haering
3. J. Peters

In Plant Science

1. Kim Nasmyth
2. C. Haering

Citations in the corpus

• The acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent manner (2007, neutral): “However, in higher eukaryotes, most of the cohesins are removed from the chromosome arms in prophase by the so-called “prophase pathway” (Waizenegger et al., 2000).”
• Cohesin: its roles and mechanisms. (2009, background): “The second phase involves separase, a highly conserved CD clan thiol protease, whose cleavage of Scc1 removes cohesin from chromosomes and triggers (at least in yeast) sister chromatid disjunction (130, 185, 187, 194).”
• Molecular architecture of SMC proteins and the yeast cohesin complex. (2002, background): “…ofalong with EM studies and biochemical experiments yeast cohesin, in that its cleavage is necessary for sisteron yeast Smc1 and Smc3 proteins show that SMC chromatid separation at the onset of anaphase (Hauf etprotamers fold up individually into rod-shaped moleal., 2001; Waizenegger et al., 2000).”
• Chromosomal cohesin forms a ring. (2003, background): “containing triple TEV sites was created by insertion of DNA oligos can only be opened by cleavage of Scc1 at anaphase into the existing single TEV sites: the final sequence was: 250Donset (Waizenegger et al., 2000).”
• The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint (2003, methodology): “Antibodies The following antibodies were used: rabbit polyclonal against Cdc27, securin (Waizenegger et al., 2000), cyclin A (Upstate Biotechnology), phospho-histone H3 (Upstate Biotechnology), Survivin (Novus Biologicals), HsCYK-4, MKLP-1 (Mishima et al., 2002), Mad2 (BAbCO), mouse monoclonal…”