Hematopoietic Stem Cell: Self-renewal versus Differentiation

By J. Seita, Irving L. Weissman. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2010

873 citations recorded by the source corpus.

The mammalian blood system, containing more than 10 distinct mature cell types, stands on one specific cell type, hematopoietic stem cell (HSC). Within the system, only HSCs possess the ability of both multipotency and self‐renewal. Multipotency is the ability to differentiate into all functional blood cells. Self‐renewal is the ability to give rise to HSC itself without differentiation. Since mature blood cells (MBCs) are predominantly short‐lived, HSCs continuously provide more differentiated progenitors while properly maintaining the HSC pool size throughout life by precisely balancing self‐renewal and differentiation. Thus, understanding the mechanisms of self‐renewal and differentiation of HSC has been a central issue. In this review, we focus on the hierarchical structure of the hematopoietic system, the current understanding of microenvironment and molecular cues regulating self‐renewal and differentiation of adult HSCs, and the currently emerging systems approaches to understand HSC biology. Copyright © 2010 John Wiley & Sons, Inc.

Subfields: Cell Biology, Hematology, Physiology

View Paper: https://www.semanticscholar.org/paper/51d1b4d8cd4669225ecd07f70d235223765c5959

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Richard J. Johnson
2. Florent Ginhoux
3. A. Trumpp

In Hematology

1. T. Suda
2. Steffen Jung
3. K. Takubo
4. Florent Ginhoux
5. A. Trumpp
6. G. Semenza

In Physiology

1. T. Suda
2. Richard J. Johnson
3. Steffen Jung
4. K. Takubo
5. Florent Ginhoux

Citations in the corpus

• Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors. (2015, background): “Hematopoiesis is the dynamic process by which self-renewing stem cells (HSCs) generate progeny that differentiate into progressively restricted cells of the erythroid, myeloid, or lymphoid lineages (Becker et al., 1963; Etzrodt et al., 2014; Orkin and Zon, 2008; Seita and Weissman, 2010; Wilson et a”
• Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. (2013, background): “The mammalian HSC system is maintained by self-renewal of quiescent long-term (LT)-HSCs and subsequent generation of short-term (ST)-HSCs, multipotent progenitors (MPPs), and various lineage-restricted progenies (Zon, 2008; Seita and Weissman, 2010).”