The 4D Nucleome Project

By Job Dekker, A. Belmont, M. Guttman, V. Leshyk, J. Lis, S. Lomvardas, Leonid A. Mirny, Clodagh C. O’Shea, P. Park, Bing Ren and 3 more. Nature, 2017

658 citations recorded by the source corpus.

The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Validated experimental technologies will be combined with biophysical approaches to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/51bf9b70f845b9bb0f97246485cedf98d6cef300

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In Molecular Biology

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4. D. Soltis
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Citations in the corpus

• Polyploidy, the Nucleotype, and Novelty: The Impact of Genome Doubling on the Biology of the Cell (2019, background): “Cremer et al. (2015, p. 2932) describe the “4D nucleome” (see also Dekker et al. 2017), emphasizing the variability of nuclear architecture in time and space and identifying “major gaps in our current understanding of how nuclear functions are interconnectedwith dynamic changes of nuclear…”