Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage.

By N. Ercal, H. Gurer‐Orhan, N. Aykin-Burns. Current Topics in Medicinal Chemistry, 2001

2,014 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Chelation in Metal Intoxication (2010, background): “Depletion of cells’ major sulfhydryl reserves seems to be an important indirect mechanism for oxidative stress that is induced by redox-inactive metals [145,146].”
Homeostasis and toxicology of essential metals (2012, background): “Evidence of induction of oxidative stress by metal exposure abounds in the mammalian literature (see Ercal et al., 2001, and Valko et al., 2005, for reviews).”
Cellular mechanisms of cadmium-induced toxicity: a review (2014, background): “Enhanced generation of ROS can overwhelm cells’ intrinsic antioxidant defences, and result in a condition known as oxidative stress in cells that can be partially responsible for the toxic effects of heavy metals (Ercal et al. 2001).”
First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid (2018, background): “Hydrogen peroxide though at low amounts tends to regulate some physiological processes such as signaling in cell proliferation, cell death, carbohydrate metabolism, mitochondrial function, and platelet activation and maintenance of normal thiol redox-balance,(37) however, at high concentrations it h”
Glutathione Is a Key Player in Metal-Induced Oxidative Stress Defenses (2012, background): “It has been suggested that metal-induced oxidative stress in cells is partially responsible for the toxic effects of metals [92].”