Co-Occurrence of 12-Month Alcohol and Drug Use Disorders and Personality Disorders in the United States

By B. Grant, F. Stinson, D. Dawson, S. Chou, W. J. Ruan, R. Pickering. Archives of General Psychiatry, 2004

645 citations recorded by the source corpus.

Background Very little information is available on the co-occurrence of different personality disorders (PDs) and alcohol and drug use disorders in the U.S. population. Objective To present national data on sex differences in the co-occurrence of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM–IV) alcohol and drug use disorders and 7 of the 10 DSM–IV PDs. Design Face-to-face interviews conducted in the 2001–2002 National Epidemiologic Survey on Alcohol and Related Conditions (N = 43,093). Setting The United States and the District of Columbia, including Alaska and Hawaii. Participants Household and group-quarters residents, age 18 and older. Results Among individuals with a current alcohol use disorder, 28.6 percent (95 percent confidence interval [CI], 26.7–30.6) had at least one PD, whereas 47.7 percent (95 percent CI, 43.9–51.6) of those with a current drug use disorder had at least one PD. Further, 16.4 percent (95 percent CI, 15.1–17.6) of individuals with at least one PD had a current alcohol use disorder, and 6.5 percent (95 percent CI, 5.7–7.3) had a current drug use disorder. Associations between PDs and alcohol and drug use disorders were overwhelmingly positive and significant (P < .05). Overall, alcohol use disorders were most strongly related to antisocial (odds ratio [OR], 4.8; 95 percent CI, 4.1–5.6), histrionic (OR, 4.7; 95 percent CI 3.8–5.8), and dependent (OR, 3.0; 95 percent CI, 1.9–4.8) PDs. Drug use disorders also were more highly associated with antisocial (OR, 11.8; 95 percent CI, 9.7–14.3), histrionic (OR, 8.0; 95 percent CI, 6.0–10.7), and dependent (OR, 11.6; 95 percent CI, 7.1–19.1) PDs. Associations between obsessive-compulsive, histrionic, schizoid, and antisocial PDs and specific alcohol and drug use disorders were significantly stronger (P < .04) among women than men, whereas the association between dependent PD and drug dependence was significantly greater (P < .04) among men than women. Conclusions The co-occurrence of PDs with alcohol and drug use disorders is pervasive in the U.S. population. Results highlight the need for further research on the underlying structure of these disorders and the treatment implications of these disorders when comorbid.

Subfields: Clinical Psychology, Epidemiology

View Paper: https://www.semanticscholar.org/paper/516812112158ce3bceb323b8acfb0b5cc9587433

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Psychology

1. D. Hasin
2. David Goldman
3. G. Koob
4. B. Grant
5. G. Oroszi
6. F. Ducci

In Epidemiology

1. D. Hasin
2. Carlos Blanco
3. G. Koob
4. Mayumi Okuda
5. M. Le Moal
6. C. Lopez-Quintero
7. David Goldman
8. Shuai Wang

Citations in the corpus

• Probability and predictors of transition from first use to dependence on nicotine, alcohol, cannabis, and cocaine: Results of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) (2010, methodology): “Personality disorder diagnosis required long-term patterns of social and occupational impairment (Grant et al., 2004d).”
• Addiction and the brain antireward system. (2008, result): “Recent data (Grant et al. 2004a–c) show similar results (21%–29% for mood disorders, 22%– 25% for anxiety, and 32%–70% for personality disorders).”
• The genetics of addictions: uncovering the genes (2005, background): “Therefore, it is crucial to determine whether common disease origins determine the excess aggregation of these disorders observed in populations and in familie”