Myeloid Suppressor Lines Inhibit T Cell Responses by an NO-Dependent Mechanism1

By A. Mazzoni, V. Bronte, A. Visintin, J. H. Spitzer, E. Apolloni, P. Serafini, Paola Zanovello, D. Segal. Journal of Immunology, 2002

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Subfields: Immunology

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Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF-β11 (2009, background): “MDSC can also inhibit T cell proliferation and activation through arginase-1 or NO synthase 2 (25, 26).”
Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. (2005, background): “It has recently reported that suppression of immune cell function associated with chemotherapy [33], radiotherapy [34], infection [35,36] and in tumor-bearing hosts [37] is mediated by production of NO produced by immature myeloid cells that are massively generated under these conditions [38–40].”
Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. (2010, background): “Since Nos2 is pivotal in MDSC-induced suppression in C57BL/6 mice (Mazzoni et al., 2002; Serafini et al., 2006), we compared the in vitro inhibitory activity of CD11b+ splenocytes from tumor-bearing mice (spleen MDSCs) and BM-MDSCs from either wild-type or Nos2 ablated mice.”