A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration.

Proceedings of the National Academy of Sciences of the United States of America, 2005

2,084 citations recorded by the source corpus.

Subfields: Immunology, Ophthalmology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/50a76e6fec50fbf9d6a3f090f61a5b312cac09ca

Citations in the corpus

• The Impact of Oxidative Stress and Inflammation on RPE Degeneration in Non-neovascular AMD (2017, positive): “C5b-9 localizes to the choriocapillaris rather than the retina or RPE, and increases in the choriocapillaris with aging (Hageman et al., 2005; Seth et al., 2008).”
• Para-inflammation in the aging retina. (2009, positive): “Further studies have shown that a number of complement components including CFH (Chen et al., 2007; Hageman et al., 2005; Kim et al., 2009), complement factor B (CFB) (Chen et al., 2008b), and C3 (Wang et al., 2004) can be synthesised locally by RPE cells.”
• Seven New Loci Associated with Age-Related Macular Degeneration (2013, neutral): “Lars G Fritsche [1,2, *], Wei Chen [2,3,*], Matthew Schu [4,*], Brian L Yaspan [5,6,*], Yi Yu [7,*], Gudmar Thorleifsson [8], Donald J Zack [9,10,11,12], Satoshi Arakawa [13],”
• The Role of the Anaphylatoxins in Health and Disease (2009, neutral): “Similar scenarios may apply to Parkinson disease (McGeer and McGeer, 2004), Huntington's disease (Singhrao et al., 1999) and age relate macular degeneration (AMD) (Hageman et al., 2005).”