Controlled PEGylation of Monodisperse Fe3O4 Nanoparticles for Reduced Non‐Specific Uptake by Macrophage Cells

By Jin Xie, Chenjie Xu, Nathan Kohler, Yanglong Hou, Shouheng Sun. 2007

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Surface Functionalization of Nanoparticles with Polyethylene Glycol: Effects on Protein Adsorption and Cellular Uptake. (2015, background): “In agreement with previous studies, we have observed that PEGylation reduces NP uptake by cultured cells.(5,6,8,9,11,14,15,17) Whereas proteins were adsorbed onto the outer surface of the non-PEGylated NPs, proteins likely reside inside the PEG layer for PEGylated NPs.”
Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging (2009, background): “At sizes below 100,000 Da, PEG polymers are considered amphiphilic and are soluble in water as well as in many organic solvents, including methylene chloride, ethanol, toluene, acetone, and chloroform.”
Magnetite nanoparticles for removal of heavy metals from aqueous solutions: synthesis and characterization (2013, neutral): “Furthermore, the magnetic particles can be tailored to separate specific metal species in water, wastes or slurries (Yantasee et al. 2007; Ngomsik et al. 2006; Liu et al. 2008).”
Catechols as versatile platforms in polymer chemistry (2013, background): “47 concerned[229-233], final products were usually designed for metal nanoparticles stabilization such as FePt or Fe3O4 in the biomedical field (Fig.”