Nervous system involvement after infection with COVID-19 and other coronaviruses

By Yeshun Wu, Xiaolin Xu, Zijun Chen, J. Duan, K. Hashimoto, Ling Yang, Cunming Liu, Chun Yang. Brain, behavior, and immunity, 2020

1,822 citations recorded by the source corpus.

Highlights • Coronoviruses not only affect the respiratory system, but also have deleterious effects on the central nervous system.• Most neurological diseases could be caused by coronoviruses invasion.• Coronoviruses cause nerve damage via diverse pathways.

Subfields: Infectious Diseases, Neurology

View Paper: https://www.semanticscholar.org/paper/6494984f43785e839a9b7b7f8ee8e9c2cb5148f2

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1. S. Frank
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Citations in the corpus

• Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors (2020, positive): “Coronaviruses could induce psychopathological sequelae through direct viral infection of the central nervous system (CNS) or indirectly via an immune response (Wu et al., 2020).”
• Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms (2020, neutral): “Recent articles also, discuss routes and mechanisms of CoV neurotropism (Vavougios, 2020; Yeshun Wu et al., 2020) .”
• Postmortem examination of COVID‐19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction (2020, background): “Several investigations have suggested neuronal manifestations of SARS-CoV-2, ranging from smell and taste dysfunction to central dysregulation of breathing.(55) In our series, four brains were analysed histologically, and no inflammatory infiltrates or neuronal necroses were observed.”