Circadian Integration of Metabolism and Energetics

By J. Bass, J. Takahashi. Science, 2010

1,819 citations recorded by the source corpus.

Circadian clocks align behavioral and biochemical processes with the day/night cycle. Nearly all vertebrate cells possess self-sustained clocks that couple endogenous rhythms with changes in cellular environment. Genetic disruption of clock genes in mice perturbs metabolic functions of specific tissues at distinct phases of the sleep/wake cycle. Circadian desynchrony, a characteristic of shift work and sleep disruption in humans, also leads to metabolic pathologies. Here, we review advances in understanding the interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes and implications for rational therapeutics for these conditions.

Subfields: Cognitive Neuroscience, Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/5032eecf0a00a2f13a8ebc87abeb76d5aa744aa4

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Citations in the corpus

Bile Acid Signaling in Metabolic Disease and Drug Therapy (2014, background): “Disruption of primary clock genes, CCGs, and clock output genes exacerbates the development of metabolic diseases including fatty liver disease, diabetes, and obesity (Bass and Takahashi, 2010; Feng et al., 2011).”
Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain (2013, background): “Sleep influences energy metabolism (14, 15), and one function of sleep is to conserve energy (16).”
Social jetlag and obesity. (2012, background): “The circadian clock also regulates energy homeostasis [16], and its disruption—as with social jetlag—may contribute to weight-related pathologies [17–19].”
The two‐process model of sleep regulation: a reappraisal (2016, background): “Thus, in the wake-feeding episode glycogen and cholesterol synthesis are promoted, whereas in the sleep-fasting episode gluconeogenesis and glycogenolysis prevail (Bass and Takahashi, 2010).”
CENTRAL AND PERIPHERAL CIRCADIAN CLOCKS IN MAMMALS (2012, background): “However, the discovery of " clock genes " led to the realization that the capacity for circadian gene expression is widespread throughout the body (Dibner et al. 2010).”
Time restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high fat diet (2012, positive): “Conversely, disruption of diurnal rhythms is commonly found in animal models of diabetes and obesity lacking specific metabolic regulators (reviewed in Bass and Takahashi, 2010).”
Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption (2012, background): “These findings and others (35), together with our current results, suggest that synchronized central and peripheral circadian processes may also be necessary for the optimal regulation of energy homeostasis in mammals.”
The AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism (2011, positive): “AMPK activation has recently been linked to regulation of the circadian clock, which couples daily light and dark cycles to the control of physiology in a wide variety of tissues through tightly coordinated transcriptional programme”