Generation of Solution and Surface Gradients Using Microfluidic Systems

By N. Jeon, S. Dertinger, D. Chiu, Insung S. Choi, A.D. Stroock, George M. Whitesides. 2000

962 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/4fde5f85b28ed0f8516d35819af32e8c60685e42

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In Biomedical Engineering

Citations in the corpus

Controlled microfluidic interfaces (2005, background): “As a result, concentration gradients with complex profiles can be generated by feeding a small number of fluid streams with initial concentrations of diffusible substances into a pyramidal microfluidic networ”
Microfabrication meets microbiology (2007, background): “Networks of branching and recombining microchannels can be used to produce stable gradients of biomolecule”
Soft lithography in biology and biochemistry. (2001, methodology): “Figure 7 shows a “Christmas tree structure” fabricated to generate gradients and illustrates its use with fluorescein using three inlet reservoirs (136, 137).”
Optimizing layout of obstacles for enhanced mixing in microchannels (2002, methodology): “Figure 6 Evolution of design with obstacles in the Y-channel To evaluate the performance of mixing, mixing efficiency can be calculated by equation 16 [21],”
Bio-MEMS : Technologies and Applications (2006, methodology): “Laser ablation is a direct technique in which the energy of a laser pulse is used to break bonds in a polymer molecule and to remove the decomposed polymer fragments from the ablation region [24,29,30].”
Magnetically-actuated artificial cilia for microfluidic propulsion (2009, background): “Classical means for fluid-propulsion do no longer suffice at these small length scales, which has led to a search for new methods dedicated for fluid propulsion at the micron-scale, such as micropumps [10], syringe pumps [13, 8] or by exploiting electro-magnetic actuation, as in electro-osmotic [18,”