Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency.

By S. Farooqi, G. Yeo, J. Keogh, Shiva Aminian, S. Jebb, G. Butler, T. Cheetham, S. O’Rahilly. Journal of Clinical Investigation, 2000

791 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/4f9b1a3214f426661839116359206c3651d271e6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. I. S. Farooqi
2. Roger Cone

In Epidemiology

1. Roger Cone

In Nutrition and Dietetics

1. I. S. Farooqi
2. Roger Cone
3. T. Lobstein
4. Barry M. Popkin

Citations in the corpus

• Anatomy and regulation of the central melanocortin system (2005, background): “Further studies now show that haploinsufficiency of the MC4R in humans is the most common monogenic cause of severe obesity, accounting for up to 5% of case”
• Pediatric Obesity-Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline. (2017, positive): “Heterozygous mutations in the melanocortin 4 receptor are found in 2% to 5% of subjects with extreme pediatric obesity, making this the most common genetic form of obesity (99, 100) (Table 3).”
• Obesity in children and young people: a crisis in public health. (2004, background): “Defects in the melanocortin 4 receptor cause a severe obesity syndrome that is dominantly inherited and may account for up to 5% of patients with severe, early-onset obesity (265).”