Heparin prevents antiphospholipid antibody–induced fetal loss by inhibiting complement activation

By G. Girardi, P. Redecha, J. Salmon. Nature Medicine, 2004

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Pathogenesis of antiphospholipid syndrome: understanding the antibodies (2011, background): “The hypothesis that complement is involved in the fetal loss induced by aPL is further supported by the demonstration that the protective effect of heparin in the mouse model is linked to the anticomplement, rather than to the anticoagulant, activity”
Silica and titanium dioxide nanoparticles cause pregnancy complications in mice. (2011, background): “However, it has recently been shown that heparin acts in many ways other than as an anticoagulan”
The journey of a drug-carrier in the body: an anatomo-physiological perspective. (2012, background): “Plasma contains anticoagulants which can interfere with complement cascade activation [84] while serum is depleted of coagulation proteins (fibrinogen and others) [85].”