Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium.

By K. Salnikow, A. Zhitkovich. Chemical Research in Toxicology, 2008

883 citations recorded by the source corpus.

Subfields: Environmental Chemistry, Health, Toxicology and Mutagenesis

View Paper: https://www.semanticscholar.org/paper/4f943fb92acdc3d0bb0dada3ebe9ed502de45fa6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Health, Toxicology and Mutagenesis

1. K. Jomová
2. Zhushan Fu
3. Shuhua Xi
4. A. Hartwig
5. M. Valko
6. D. Beyersmann
7. A. Valavanidis

Citations in the corpus

• Prevalence of exposure of heavy metals and their impact on health consequences (2018, background): “Arsenic Ingestion via drinking water, food, smoking, occupational Smelting, fossil fuel burning, agricultural pesticides, industrial waste(77,82) Arsenicosis, psychological effects,(115,293,294) decreased mental performance,(120) hypertension, cardiovascular disease risk, carotid atherosclerosis and”
• Nickel: Human Health and Environmental Toxicology (2020, background): “Salnikow and Zhitkovich found in vivo changes in DNA methylation in nickel-induced tumors [99].”
• The effects of heavy metals on human metabolism (2019, background): “Governments must therefore take important steps to protect the population from this potential hazard to people’s health by advising people to avoid fish species that contain high levels of arsenic and mercury(Salnikow and Zhitkovich 2008).”
• Pulmonary Oxidative Stress, Inflammation and Cancer: Respirable Particulate Matter, Fibrous Dusts and Ozone as Major Causes of Lung Carcinogenesis through Reactive Oxygen Species Mechanisms (2013, background): “In addition to oxidative DNA damage, metals cause changes in DNA methylation and histone modifications, leading to epigenetic silencing or reactivation of gene expression [107–109].”
• Arsenic: toxicity, oxidative stress and human disease (2011, background): “Trivalent arsenic has been demonstrated to exhibit a greater toxicity than the corresponding pentavalent forms, in addition to a far more pronounced ability to release iron from the iron‐ storage protein ferritin (Salnikow and Zhitkovich, 2008).”
• Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms (2008, background): “In addition to its genotoxic activity, nickel deregulates normal growth control by several epigenetic mechanisms (reviewed by Salnikow and Zhitkovich 2008).”
• Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic (2021, background): “Ternary adducts are predominant and more toxicologically relevant in mammalian cells (Salnikow and Zhitkovich, 2008; Zhitkovich, 2011).”
• Chromium toxicity and tolerance in plants (2013, background): “Cr(VI) is highly mutagenic, because unlike other metals it directly reacts with DNA forming DNA–protein and DNA– DNA cross-links (Salnikow and Zhitkovich 2007).”