MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

By S. Zheng, Eugene Palovcak, Jean-Paul Armache, K. Verba, Yifan Cheng, David A. Agard. 2017

7,359 citations recorded by the source corpus.

Subfields: Atomic and Molecular Physics, and Optics, Structural Biology, Surfaces, Coatings and Films, Numerical Methods & Scientific Computing, Computational Biology & Bioinformatics

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Atomic and Molecular Physics, and Optics

1. Erik Lindahl
2. David Baker
3. Björn Forsberg
4. Sjors H. W. Scheres
5. Dari Kimanius

In Structural Biology

1. Sjors H. W. Scheres
2. Takanori Nakane
3. Jasenko Zivanov
4. Dari Kimanius
5. Erik Lindahl
6. Björn Forsberg
7. D. Veesler
8. W. Hagen

In Surfaces, Coatings and Films

1. Dari Kimanius
2. Erik Lindahl
3. Takanori Nakane
4. M. A. Tortorici
5. Björn Forsberg
6. Jasenko Zivanov
7. W. Hagen
8. D. Veesler

In Numerical Methods & Scientific Computing

1. Takanori Nakane
2. Frank DiMaio
3. David Baker
4. Jasenko Zivanov
5. Sjors H. W. Scheres

In Computational Biology & Bioinformatics

1. Frank DiMaio
2. David Baker
3. W. Sheffler
4. J. Dauparas
5. M. A. Tortorici
6. Y. Xiang
7. Xinquan Wang
8. M. Gui

Citations in the corpus

• The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands (2022, neutral): “The micrographs were dose-weighted and beam induced motion corrected through MotionCor2 (Zheng et al., 2017).”
• Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus (2019, methodology): “Movie frames were aligned with MotionCor2 (Zheng et al., 2017), with the use of dose weighting.”
• New tools for automated high-resolution cryo-EM structure determination in RELION-3 (2018, methodology): “We aligned the original, super-resolution movies using the UCSF implementation of MotionCor2 (version 1.0.5) ( Zheng et al., 2017 ) in four by four patches with dose weighting and two-fold binning.”
• Hallucinating protein assemblies (2022, methodology): “Dose-weighting and image alignment of all 50 frames was carried out using MotionCor2 ( 49 ) with 5X5 patch or with cryosparc v2 patch alignment tool with default parameters.”
• Structure of the class D GPCR Ste2 dimer coupled to two G proteins (2020, neutral): “Micrographs were subjected to beam-induced motion correction using MotionCor2 42 by dividing each frame into 5 x 5 patches.”