Therapeutic antibodies for autoimmunity and inflammation

By A. Chan, P. Carter. Nature reviews. Immunology, 2010

847 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/4eeb7894b22e6170268527b71408af02fba8b8c1

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In Immunology

In Radiology, Nuclear Medicine and Imaging

Citations in the corpus

Murine Models of Systemic Lupus Erythematosus (2011, background): “Abbreviations ADCC: Antibody dependent cell-mediated cytotoxicity aGVHD: Acute graft-versus-host-disease ALPS: Autoimmune lymphoproliferative syndrome ANA: Antinuclear antibody APC: Antigen presenting cells anti-RNP antibodies: Anti-ribonucleoprotein antibodies: anti-Su, anti-Sm, and anti-U1RNP BAFF”
Computationally Designed Bispecific Antibodies Using Negative State Repertoires (2016, background): “IgG antibodies and BsAbs make attractive therapeutics due to their long serum half-lives (mediated by Fc/Neonatal-receptor interactions (Chan and Carter, 2010)), their ability to recruit the patient’s own immune system (mediated by CH2/FcγR interactions (Nimmerjahn Structure.”
Antibody therapy of cancer (2012, background): “The broad range of antibody engineering approaches that have been used in the clinic has recently been reviewe”
Sepsis: current dogma and new perspectives. (2014, background): “Moreover, as ongoing investigations reveal other indications for treating patients with diseases attributable to inflammatory and autoimmune mechanisms, the use of these agents is likely to grow (Chan and Carter, 2010).”
FGF/FGFR signaling in health and disease (2020, background): “Targeting pro-inflammatory factors such as IL-6 and TNF-α has been shown to be an effective therapy for some inflammatory diseases, and therapeutic antibodies are also promising strategy to treat inflammatory diseases.(526,527) From the above studies, we can conclude that FGF signaling has close rel”
Cognizance of Molecular Methods for the Generation of Mutagenic Phage Display Antibody Libraries for Affinity Maturation (2019, background): “The broad application of naïve libraries has allowed them to be used to develop antibodies against targets relevant to cancer [72], autoimmune diseases [73,74], infectious diseases [17,75], and other diseases for either diagnostic or therapeutic applications.”
Strategies and challenges for the next generation of therapeutic antibodies (2010, background): “Most cytokines and associated receptors seem to be valuable targets for the treatment of immunological disorders, as shown by the large number of antibodies that have already been approved (such as those specific for TNF, interleukin-1 (IL-1), IL-2 receptor (IL-2R), IL-6R, IL-12, IL-23 and receptor ”