Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter.

By C. Lai, Osama Mardini, M. Ericsson, Shilpa Prabhakar, C. Maguire, J. Chen, B. Tannous, X. Breakefield. ACS Nano, 2014

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Extracellular vesicles in cancer: cell-to-cell mediators of metastasis (2016, background): “Recently, development of a biotinylated EV-Gaussia luciferase reporter enabled in vivo tracking of IV-administered EVs (Lai et al., 2014).”
Engineering exosomes for targeted drug delivery (2021, methodology): “For example, bioluminescence and fluorescence tracking of exosomes were realized by enzymatic biotinylation of exosomes with biotin ligase [95].”
Biodistribution and Delivery Efficiency of Unmodified Tumor-Derived Exosomes (2014, result): “Regardless, our results demonstrate the rapid uptake of exosomes by the liver and spleen, consistent with previous reports examining the biodistribution of exosomes [20, 22, 23].”
Exosomes and their roles in immune regulation and cancer. (2015, background): “It has been described that the expression of integrins, adhesion molecules, lipids, and other molecules on EVs contribute to the attachment and fusion of the injected vesicles to “acceptor” cells [8,103,153–155].”