T-cell exhaustion in the tumor microenvironment
By Yan Jiang, Yu Li, B. Zhu. Cell Death and Disease, 2015
1,045 citations recorded by the source corpus.
T-cell exhaustion was originally identified during chronic infection in mice, and was subsequently observed in humans with cancer. The exhausted T cells in the tumor microenvironment show overexpressed inhibitory receptors, decreased effector cytokine production and cytolytic activity, leading to the failure of cancer elimination. Restoring exhausted T cells represents an inspiring strategy for cancer treatment, which has yielded promising results and become a significant breakthrough in the cancer immunotherapy. In this review, we overview the updated understanding on the exhausted T cells in cancer and their potential regulatory mechanisms and discuss current therapeutic interventions targeting exhausted T cells in clinical trials.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/4ebaa4cf1a4fb50678aec6c935eeb9c5c5278e36
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
- P. Luo
- Q. Cheng
- Zaoqu Liu
- Libo Wang
- Xinwei Han
- X. Ge
- Qimeng Liang
- Yuqing Ren
Citations in the corpus
- Systemic Immunity is Required for Effective Cancer Immunotherapy (2017, neutral): “Systemic Immune Responses Are Required for Tumor Eradication Effective immunotherapy induces marked changes in both the microenvironment and the periphery, but the prevailing dogma holds that productive immunotherapy functions by reinvigorating immune cells that are actively suppressed in the tumor ”
- Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer (2017, neutral): “Interestingly, these T cells also manifested immuno-suppressive phenotypes of exhausted 39,40 or regulatory T cells 41 .”
- Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing. (2017, neutral): “The percentages of exhausted CD8+ T cell were increased significantly in tumor samples (Figure 2E), in agreement with previous findings (Jiang et al., 2015).”
- Immunosenescence: molecular mechanisms and diseases (2023, background): “Moreover, lifelong chronic antigen loading also leads to T lymphocyte population exhaustion to fill the immune space, exacerbating the reduced T-cell repertoire.(69) This suggests that distorted T-cell pools resulting from immunosenescence can be accelerated by long-term latent antigens in elderly i”