Systemic manifestations and comorbidities of COPD

By P. Barnes, Bartolome Celli. European Respiratory Journal, 2009

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Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease. (2013, background): “Persistent low-grade systemic inflammation may be the link between COPD and comorbidities (17).”
Editorial: Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 Guidelines for COPD, Including COVID-19, Climate Change, and Air Pollution (2023, positive): “Становится всё более оче видным, что наличие сопутствующих заболеваний при ХОБЛ оказывает выраженное влияние на качество жизни и выживаемость пациентов [100].”
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. (2007, background): “It is increasingly recognized that many patients with COPD have comorbidities and that these have a major impact on their quality of life and survival (42).”
Comorbidities and risk of mortality in patients with chronic obstructive pulmonary disease. (2012, background): “COPD is a complex respiratory disease frequently associated with systemic manifestations (25, 26).”
Characterisation of COPD heterogeneity in the ECLIPSE cohort (2010, background): “Likewise, our results also confirm that co-morbidities occur more frequently in patients with COPD than in controls [22].”